From Farming to Pharma for Patients.

A complete and innovative supply chain for the development of the medical use of cannabinoids.

“Enecta works for the development of extracts and therapeutic solutions based on phytocannabinoids, starting from selected plants cultivated according to the highest quality standards.

The potential of the cannabis plant has led Enecta to create GreenValley, an agricultural company committed to bringing innovation into agricultural techniques and to developing the entire range of cannabis’ industrial perspectives.

The therapeutic scopes of cannabinoids are still largely to be explored.
This is why Enecta supports the commitment of researchers.”

Towards the future of Cannabis

Research into the potential of cannabis opens up an ever-richer range of applications.

A phyto-complex that has hundreds of components, which need to be studied separately, exploring the therapeutic perspectives of each individual active ingredient, and as a whole (entourage effect), to assess the interactions that can lead to synergies or antagonism, also in relation to administration in support of other pharmacological practices.

At global level, modern health services are increasingly embracing cannabinoid-based therapies. However, a great deal of effort is still needed to further investigate each line of  research, conduct clinical trials, gather evidence and ensure more and more patients access to appropriate care. This is why it is essential to constantly devote to the production of homogeneous and standardized varieties of inflorescences, and to the identification and development of specific extraction techniques for each cannabinoid.

ENECTA MILESTONES

2013

Enecta BV is created in Amsterdam

  • Advisory services and  markets  phytocannabinoids  extracts in Europe and the  United States

2016

Approval of the Italian law  ‘Provisions for the  promotion of the  cultivation and the agro-industrial chain of  cannabis’ No. 242/2016

2017

Enecta established a HQ in Bologna.

  • Start of the consultancy  service with the the University of Bologna:  analytical study for the  characterization of  Cannabinoids active principles in cannabis
  • GreenValley, agricultural  company partner of Enecta
  • Enecta starts its  investments in Greece

2018

Enecta srl is created

  • Launch of the collaboration between GreenValley and CREA-CI (Research Center for Cereal Growing and Industrial Crops, CREA): study on the optimization of agronomic techniques for the cultivation of Cannabis sativa L. for the production of extracts, free of psychoactive substances, for industrial use.
  • Enecta Greece is created.
  • Start of collaborations and donations for research activities with the University of Bologna, University of Campania Luigi Vanvitelli, University of Genoa.

Commitment and Knowledge

The therapeutic scopes of cannabinoids have still to be widely explored. For this reason, Enecta
supports the researchers’ commitment and the dissemination and scientific debate on medical cannabis.

Commitment: Research

Enecta supports the commitment of researchers

 

Alma Mater Studiorum – University of Bologna Department of Agrifood Science and Technologies

2017-2018

  • Analytical study for the characterization of Cannabinoids active principles in Cannabis and writing of Paper:  Cardenia V., Gallina Toschi T. et al., Development and validation of a Fast gas chromatography/mass spectrometry method for the determination of cannabinoids in Cannabis sativa L, Journal of Food and Drug Analysis (2018). https://www.jfda-online.com/article/S1021-9498(18)30106-6/fulltext

2018-2021

  • Supervision and funding of scholarship within the PhD program in Agricultural, Environmental  and Food Science and Technology “Harmonized methods of analysis of cannabis for medical,  phyto-therapeutic, food and industrial use: development and validation of methods for quality  control of plant raw material, and development of extractive techniques and of preparation of  derivatives, according to the market destination.”

Mara Mandrioli ,Matilde Tura,Stefano Scotti, Tullia Gallina Toschi, Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in Cannabis sativa L., Molecules (2019). https://www.mdpi.com/1420-3049/24/11/2113/htm#

 

Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”

2018-2019

Collaboration and funding of research activity “Study and analysis of the possible molecular,  behavioral and/or sensory modifications associated with a condition of head injury in a murine  model of mild TBI and the possible pharmacological effect of the formulations.
Writing of paper: Carmela Belardo, Livio Luongo et al., Oral Cannabidiol prevents chronic pain and neurological dysfunctions in a mouse model of mild traumatic brain injury, Front. Pharmacol.(2019). 
https://www.frontiersin.org/articles/10.3389/fphar.2019.00352/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE

 

Camerino University – Pharmaceutical Sciences and Health Products School

2018-2019

Collaboration and financing research activity “Role of CBD in endometrial cancer; pre-clinical experimentation for the development of new formulations and potential developments of in vivo studies “

 

Pediatric Neurology and Muscular Diseases Unit DINOGMI – Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa

2019

Donation for the research “Predictors of clinical response and events adverse to cannabidiol in  drug-resistant pediatric epilepsies”.

Commitment: Knowledge

Enecta supports the dissemination and scientific debate on medical cannabis.

 

Update on medical cannabis
November 11st, 2017, Rovigo (IT)

Main speakers:

  • Giovanni Appendino, Full Professor of Organic Chemistry, Faculty of  Pharmacy, University of Piemonte Orientale
  • Giampaolo Grassi, Lead Researcher, CREA-CIN
  • Alberto Ritieni, Professor of Food Chemistry, Department of Pharmacy, University of the Studies of Napoli Federico II


Medcannabis Science Conference, Balkannabis

June 1st, 2018, Athens

Main speakers:

  • Ethan Russo, Director of Research and Development, Cannabis and Cannabinoids Institute (ICCI)
  • Tanja Bagar, CEO and Chairman of the Expert Council, International  Institute of Cannabinoids ICANNA
  • Pavel Pachta, Expert in International Drug Regulation


Cannabeta, Medical Cannabis Talks www.cannabeta.eu
Applications and potential of Medical Cannabis
July 6th, 2018, Athens

Main speakers:

  • Pasquale Striano, Associate Professor of Pediatrics, Department of  Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and  Child Science (DINOGMI), University of Genoa – G. Gaslini Institute
  • Livio Luongo, Researcher, University of Campania Luigi Vanvitelli
  • Vittorio Andrea Guardamagna, Director of Palliative Care and Pain Therapy, European Oncology Institute – EIO


Medical and industrial Cannabis. Uses of the plant and perspectives of an emerging supply chain

October 27th, 2018 – Codigoro (Ferrara)

Main speakers:

  • Massimo Nabissi, Associate Professor, School of Pharmaceutical Sciences  and Health Products, University of Camerino
  • Tullia Gallina Toschi, Ordinary Professor, Department of Agro-Food Sciences and Technologies, Alma Mater Studiorum – University of Bologna
  • Laura Bardi, Research Director, CREA-IT

Cannabeta, Medical Cannabis Talks – www.cannabeta.eu
“The role of the anesthesiologist in cannabinoid therapy”
promoted by the Hellenic Society of Anesthesiology and the Hellenic Society of Algology, with the support of Enecta, under the initiative of Cannabeta – Medical Cannabis Talks
February 2nd, 2019, Stavros Niarchos Foundation Cultural Center, Athens

Main speakers:

  •      Gioacchino Calapai, Prof. of Pharmacology and Toxicology, University of Messina, Italy
  •      Domenico Quattrone, Pain Therapy Unit, Grande Ospedale Metropolitano “Bianchi – Melacrino – Morelli”, Reggio Calabria, Italy
  •      Katerina Antoniou, Αssociate Professor of Pharmacology, University of Ioannina


XVIII National Congress UNISVET (Italian Veterinary Society), Oncology Master Class sponsorship
February 15th to 17th, Mi.Co., Milan

  • Vincenzo Rondelli, DVM, PhD, Head of Anesthesiology and Pain Therapy, Veterinary Institute of Novara, “The use of cannabinoids in veterinary medicine and future perspectives on their use”.

     

Cannabeta, Medical Cannabis Talks – www.cannabeta.eu
New horizons in cannabis research: medical and food applications
May 3rd 2019, Complesso SS. Marcellino e Festo – University of the Studies of Napoli “Federico II”
May 6th 2019, “Sapienza” University of Rome

Main speakers:

  • Vincenzo di Marzo, Institute of Biomolecular Chemistry of the National Research Council (ICB-CNR) in Pozzuoli, Naples; Institut Universitaire de Cardiologie et Pneumologie du Quèbec et Institut sur la Nutrition et les Aliments Fonctionnels, Université Laval, Quebec City, Canada.     
  • Mauro Maccarrone, Biomedical University of Rome, Medicine Department
  • Cristina Sánchez García, Departamento de Bioquímica y Biología Molecular, Universidad Complutense de Madrid

Specialized seminar: Genetic epilepsies towards a precision therapy

May 18th 2019, Hotel NH Bologna De La Gare

 Main speakers:

  • Roberta Cilio, Clinica Saint- Luc, Université catholique de Louvain
  • Pasquale Striano, Associate Professor of Pediatrics, Department of  Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and  Child Science (DINOGMI), University of Genoa – G. Gaslini Institute

Farms

Green Valley is Enecta’s official partner farm in the cultivation of Cannabis for the extraction of CBD and other non-psychotropic active ingredients. Founded in 2017, Green Valley has invested in the cultivation of over 30 hectares of land by engaging fields between Abruzzo and Veneto with  three different varieties of industrial hemp Futura 75, Santhica 27 and Finola.

It conducts a research project on the optimization of agronomic techniques for the cultivation of Cannabis sativa L. together with CREACI, the Research Center for Cereal Agriculture and Industrial Crops of the Council for research in agriculture and the analysis of the agrarian economy.

It has developed new models of mechanization of the cultivation, harvesting, handling and storage  phases, for a better, faster and more secure yield of the crop. These techniques will soon be available to farmers who want to collaborate with Green Valley in the cultivation of cannabis, complying with high-quality standards.

  • Cultivation on selected fields without use of pesticides
  • Guidelines on Good Agricultural and Collection Practices (GACP)
  • Monitoring of contaminants according to specific European Pharmacopoeia

Proprietary Genetics

Enecta developed and registered 13 varieties at the Community Plant Variety Office –  Community Plant Variety Office (CPVO).

 

  • Administration of percentages of active ingredients with a calibrated dosage,  according to the pathology and the clinical condition of the patient
  • Optimization of the extractive process of the different phytocannabinoids
  • Availability of certified varieties, registered with vegetative reproduction = guarantee  that the same source of the drug is always farmed
  • Placebo genetics = possibility of conducting reliable clinical studies
Details of Registered Genetic ENECTA

Species

Denomination

Propagation

Cannabinoids

%

Description

2018
0771

Enectone

Seed Unisex female

THC

>15%

High THC genetics  Tall plant
2018
0772

Enectacalm

Seed Unisex female

THC

>15%

High THC genetics  Short plant
2018
0773

Enectalos

Seed Unisex female

THC

12-15%

Low/medium THC  genetics
2018
0774

Enectarina

Seed Unisex female

CBD

>20%

High CBD genetics
2018
0775

Enectares

Seed Unisex female

CBD

<10%

Low/medium CBD  genetics Red color
2018
0776

Enectitaca

Seed Unisex female

CBD

<10%

Low/medium CBD  genetics Green color
2018
0777

Enectabis

Seed Unisex female

CBG

4-6%

CBG Genetics  Unisex
2018
0778

Enectria

Seed Unisex female

CBD-THC

CBD 9% THC 7%

1:1 ratio genetics
2018
0779

Enectonica

Seed Unisex female

CBD – V

3-5%

CBDV genetics  Unisex
2018
0780

Enectriump

Seed Unisex female

CBD – V

3-5%

CBDV genetics  Dioecius
2018
0781

Enectusia

Seed Unisex female

0

0

Placebo genetics

(plant with no cannobinoids

2018
0782

Enectavio

Seed Unisex female

CBD/CBG

CBD 6% CBG 4%

CBD/CBG hybrid  genetics
2018
0783

Enectalia

Seed Unisex female

THC – V

3-4% THCV

THCV Genetics

Extraction

Enecta specializes in the extraction of active ingredients from Cannabis. The extracts make the dosage safe, thanks to the possibility to monitor the exact quantity of cannabinoids present in the  extract.

 

  • Partner of italian laboratory at the forefront of cannabinoid extraction
  • Good Manufacturing Practices Protocols (GMP) and Hazard Analysis and Critical Control Points (HACCP)
  • CBD: main active ingredient extracted
  • Crystals 99.5% CBD API
  • Development of the Cannabigerol (CBG) extraction technique
  • The extraction of further active ingredients is being studied

Formulations

The experience developed by Enecta in the formulation and production of extracts and products containing cannabinoids for the pharmaceutical industry, has made it the ideal partner for world  leaders in the commercialization of medical cannabis and its extracts, which are also used to conduct clinical trials.
  • GMP processes
  • Full-spectrum extracts with high concentrations of phytocannabinoids
  • 99% CBD crystals and 99% CBG crystals
  • CBD oils with different percentages
  • Cosmetic formulations
  • Formulations with Terpenes
  • Capsules
  • Dyes

There are additional cannabinoids, CBG, CBDA, CBDV, CBN, and several terpenes, such as Myrcene, Limonene, α- and β-Pinene, β-Caryophyllene in full-spectrum formulations.

BLOG

PRESS

It’s legal, reclaims land and blocks stress: Enecta launches the “industrial” cannabis

Tuttogreen – La Stampa e Conoscenza

“The potential of the cannabis plant and of its components goes much further than what is known. For this reason, we have already invested 150 thousand of euros in agronomic and medical research and on the methods of cannabinoids analysis, in collaboration with Italian research institutes and universities” – said Jacopo Paolini, CEO of Enecta, on Tuttogreen, the monthly supplement dedicated to the environment and the agriculture of the La Stampa newspaper.

READ MORE

At the ‘Atelier of Health’,
medical and food cannabis
is being discussed

Napoli Today

Enecta took part at the Atelier della Salute, the event dedicated to the health and the prevention which was held at the Federico II Polyclinic University of Naples. The company, with Fracta Sativa, the association which promotes, defends and broadcasts the cultivation of hemp and its use in various fields, has organized an information hub on cannabis. Speaking to NapoliToday, Alberto Ritieni, who has coordinated the venture said “The Atelier della Salute is the best forum to raise awareness, in a simple but scientifically rigorous way, the therapeutic and nutraceutical potentialities that cannabis can offer to consumers and patients who suffer from some diseases”.

READ MORE

Jacopo, from Abruzzo, cultivates cannabis

Il Centro

“Today the hemp supply chain, thanks also to an important shift in the Italian regulatory framework that promotes the industrial cultivation of cannabis, has the possibility to become a propeller for the economy of the country by creating new economic opportunities and new professional figures and jobs” said Jacopo Paolini to Il Centro, a newspaper that has dedicated a detailed study to Green Valley. A detailed reportage on the Enecta farm based in Abruzzo, which also grows in Rovigo in collaboration with CreaCI, which is involved in bringing innovation into the agricultural field and in developing the industrial opportunities of cannabis for Italian economic growth.

READ MORE

The value of cannabis
“Little is known”

La Nuova Ferrara

“An opportunity of reflection to raise awareness on a shared culture about the value of cannabis” Nuova Ferrara has written an in-depth article on the day, supported by Enecta and Green Valley, about the medical and industrial use of cannabis. An event based in Codigoro which has rounded up a lively scientific community which talked about the sector’s perspective. Among the participants were Giovanni Appendino, professor of Pharmacy of Eastern Piedmont, Massimo Nabissi, associate professor of the Camerino University, Giampaolo Grassi, first researcher of Rovigo Crea-CI and professor Tullia Gallina Toschi of Bologna University.

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Development and validation of a Fast gas chromatography/mass spectrometry method for the determination of cannabinoids in Cannabis sativa L

Journal of Food and Drug Analisys

Enecta has collaborated with the Department of Agricultural Sciences and Technologies of the University of Bologna in the study of the development and validation of a new method useful for a faster and more reliable determination of phytocannabinoids in Cannabis Sativa. This improvement in the quali-quantitative analysis is a fundamental step in the study of a plant with a complex matrix like cannabis, which has hundreds of fitocannabinoids (in addition to THC and CBD). The results of the study are published by the Journal of Food and Drug Analysis. The article is now available in the PubMed library.

READ MORE

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